The actual smell and taste. To date, Ku Shen and matrine have been approved by the China Food and Drug Administration in the treatment of viral infections or gynecological disorders. Oxymatrine is one of the major alkaloid components of Sophora flavescens. Akihiko Komuro, in Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation, 2017. Sophora flavescens (Fabaceae), also known as Kushen (Chinese: ), has been an important species in Chinese medicine since the Qin and Han dynasties. 1 The roots of S. flavescens is commonly used as the traditional Chinese medicine for the treatment of pruritus, dysentery, trichomonas vaginitis, eczema, and pyogenic infections of the skin. Likewise, it has different medicinal properties and health benefits. LR-2 Xingjian, LR-5 Ligou, LR-12 Jimai, SP-9 Yinlingquan, KI-2 Rangu, KI-10 Yingu, BL-18 Ganshu and CV-2 Qugu. J Ethnopharmacol. By continuing you agree to the use of cookies. These include flavanoids kurainone, sophoraflavanone G, kushenol K, and kushenol N isolated from Sophora flavescens,31 gneyulins A and B, stilbene trimers, and noidesols A and B, dihydroflavonol-C-glycosides, from the bark of Gnetum gnemonoides,32 alstiphyllanines E–H, picraline, and ajmaline-type alkaloids from Alstonia macrophylla,33 and luteolin, apigenin, 6-C-pentosyl-8-C-hexosyl apigenin, and 6-C-hexosyl-8-C-pentosyl luteolin isolated from Cynodon dactylon.34. It is used both internally and externally in the treatment of vaginitis, eczema, pruritis, ringworm, leprosy, syphilis, scabies and itching allergic reactions. It serves as a bitter tonic, diuretic and also helps to treat skin diseases such as eczema and pruritus. Anika Niambi Al-Shura BSc., MSOM, Ph.D, in Integrative Cardiovascular Chinese Medicine, 2014, In The Treatment of Pain with Chinese Herbs and Acupuncture (Second Edition), 2011. Sophora flavescens is a Chinese medicinal herb used for the treatment of gastrointestinal hemorrhage, skin diseases, pyretic stranguria and viral hepatitis. Sophora flavescens Ait. Helps with: viral hepatitis, enteritis, cancer prevention, viral myocarditis, gastrointestinal hemorrhage, eczema, psoriasis and skin care. Effects of alkaloids on peripheral neuropathic pain: a review. Glabrol increased sleep duration and decreased sleep latency in a dose-dependent manner. Alibaba Chinese manufacturer supply hot selling matrine 10% You May Like Sophora flavescens is a species of plant in the genus Sophora a genus of the Fabaceae family, that contains about 52 species, nineteen varieties, and seven forms that are widely distributed in Asia, Oceanica, and the Pacific islands. by Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland, Oregon. The herb used in different herbal formulations is commonly known with specific pharmacological properties for treatment of liver disorders and other diseases such as arrhythmia, eczema and skin disorders, leukopenia and bronchitis. Guo Y, Yin T, Wang X, Zhang F, Pan G, Lv H, Wang X, Owoicho Orgah J, Zhu Y, Wu H. J Ethnopharmacol. Change Yellow (Discharge) Decoction. Antifibrotic activity of oxymatrine in d-galactosamine-induced rat liver fibrosis has been predicted to be partly through inhibition of lipid peroxidation. A review paper has evaluated the efficacy of several natural products reported in the treatment of chronic HCV subjects. The root known as “Ku Shen” which means “bitter root” in Chinese, has been used in Traditional Medicine for two thousand years to treat a variety of conditions, including diarrhea, jaundice, skin rashes, and to kill parasites. An In Vitro Study for Evaluating Permeability and Metabolism of Kurarinone. These compounds also act on the CNS, for example, by increasing the expression of GABAAα1 receptors (Xu et al., 2013). Kuhseng Extract Sophora flavescens Oxymatrine Matrine . Lin, in Side Effects of Drugs Annual, 2011. The dry roots of this plant have been used as antipyretic analgesic , bitter stomachic , anthelmintic , as an external preparation for eczema , and an agricultural insecticide in China and Japan (). There have been three reports of adverse reactions such as nausea, vomiting, dizziness, bradycardia, palpitation, ataxia, pallor, sweating, seizures, and dysphasia. 2020 Sep 9;9(9):842. doi: 10.3390/antiox9090842. This plant often grows on hillsides, grass slopes, or … Lei H, Liu A, Hou Q, Zhao Q, Guo J, Wang Z. BMC Microbiol. Sophora Flavescens is a shrub. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Saussurea involucrata: A review of the botany, phytochemistry and ethnopharmacology of a rare traditional herbal medicine. In this study the herb-drug interactions between S. flavescens and indinavir, a protease inhibitor for HIV treatment, were evaluated in rats. Sophora flavescens is a promising traditional medicine, but there is a need for more precise studies to test the safety and clinical value of its main active crude extracts and pure compounds and to clarify their mechanisms of action. The causes of eczema are many and varied, and depend on the particular type of eczema that a person has. 4), act as negative modulators of GABAC receptors containing ρ-subunits (Goutman, Waxemberg, Donate-Oliver, Pomata, & Calvo, 2003). 2020 Sep 13;2020:5267684. doi: 10.1155/2020/5267684. Salvia continues to be a rich source of GABAA modulators (Kavvadias, Monschein, Sand, Riederer, & Schreier, 2003; Kavvadias et al., 2004). and to explore their inhibitory effects on C6 glioma cells. It is an evergreen. Modern studies have confirmed the various pharmacological activities of Ku Shen such as its antitumor (Wang, You, et al., 2015; Xiao, Wang, Wang, & Shen, 2013), antiviral (Liu, Zhu, Shi, & Yang, 2003), and antiinflammatory (Ji, Cui, Liang, Guan, & Li, 2013) effects. The paper concluded that the results are promising and indicate the need for further evaluation in HCV cases (Azzam et al., 2007). Copyright © 2020 Elsevier B.V. or its licensors or contributors. Immune-stimulative activity that changes the immune response of HBV-transgenic mice from a Th2 (IL-4 and IL-10) to a Th1 (IFN-γ and IL-2) response has been also reported (Dong et al., 2002; Yang et al., 2002). Long Dan Xie Gan Wan Gentiaria Draining the Liver Pill. It is mainly used in the treatment of heat dysentery and similar ailments in the clinical. HPLC-based activity profiling of extracts the traditional Chinese herbal drug Kushen (Sophora flavescens root) led to the identification of the 8-lavandulyl flavonoids, kushenol I, sophoraflavanone G, and (−)-kurarinone, and the related chalcone kuraridine as GABAA receptor modulators (Yang, Baburin, Plitzko, Hering, & Hamburger, 2011). All over in China. Sophora Root (ku shen) What is sophora? Angelica sinensis in China-A review of botanical profile, ethnopharmacology, phytochemistry and chemical analysis. In TCM : Sophora Flavescens Root : Ku Shen Jian Meridians associated : Heart, Urinary Bladder, Liver, Small Intestine and Large Intestine. The roots of Sophora flavescens (Sf) have been widely used as a herbal medicine for the treatment of diarrhea, gastrointestinal hemorrhage, and eczema. This herbal cream contains plant-based products, like Sophora flavescens, Stemona japonica and menthol, to create a non-greasy formula for treating eczema. The anticancer and anti-infection abilities of these components are especially attractive areas for research. Guan-hua Du, ... Yong-xiang Zhang, in Advances in Pharmacology, 2016. Stinging Nettle It was first described to have anti-HCV and anti-hepatitis B virus (HBV) effects in a cell culture model (Chen et al., 2001b) and an animal model (Chen et al., 2001a). SOPHORA. The receptors are insensitive to the classic flumazenil-sensitive high-affinity modulation by benzodiazepines. Eczema is not contagious. It can flare up, disappear, and then flare up again. 26. Johnston, in Advances in Pharmacology, 2015. The species is hermaphrodite (has both male and female organs) and is pollinated by Insects. In Japan, berberine hydrochloride is available commercially. Recent evidence has pointed to the pain-relieving effect of some compounds from Ku Shen in several animal models (Fig. J Ethnopharmacol. Radix Sophorae Flavesentis contains flavonoids and alkaloids such as matrine and oxymatrine. The sop hora root (Sophora flavescens) has multiple variants; it’s called the Ku Shen in traditional Chinese medicine, it’s very commonly used. Sophora Root. However, the exact mechanisms of action of Ku Shen must be investigated in depth. Photos of Sophorae Flavescentis Radix and its medicinal components as well as its main analgesic components. The therapeutic effect of Ku Shen and its active ingredient on pain also require further evaluation. 8). The sophora root grows up to 2 feet long and one inch thick and is prepared for … Traditional uses, phytochemistry, pharmacology and toxicology of the genus Cimicifuga: A review. Sophora flavescens or Ku Shen, which in Chinese means “bitter root,” is an herb used in Traditional medicine to treat a wide variety of symptoms, with purported effects on the liver, intestinal tract, and skin. 5) was the most potent and efficacious of the positive modulators, while 3′,5′,7-trihydroxyisoflavone (Fig. Literatures show Radix Sophorae Flavescentis […] Best quality. An herbal medicine, kushen, is obtained from the roots of Sophora japonica (Sophora flavescens) and is used as an anti-inflammatory and bitter-tasting stomachic.The principal component of kushen is the piperidine alkaloid matrine. 2020 Oct 2;15:106. doi: 10.1186/s13020-020-00387-x. Zhu C, Liu N, Tian M, Ma L, Yang J, Lan X, Ma H, Niu J, Yu J. Chin Med. It has been used to treat abscess, edema, dysentery, eczema, ulcers, skin burns, skin itch and atopic dermatitis in traditional medicine for thousands of years 1, 2, 3. Extracts are taken either orally or by injection. After withdrawal and symptomatic treatment, there was full recovery in eight cases, and the rest improved markedly. The broad spectrum of biological activities associated with Sophora flavescens has been considered a valuable resource in both traditional and modern medicine. Location. Eczema is characterized by itchy, dry, rough, flakey, inflamed, and irritated skin. Traditional uses, phytochemistry, and pharmacology of the genus Acer (maple): A review. 2020 Aug 31;20(1):272. doi: 10.1186/s12866-020-01956-8. (A) Fenugreek C-glycosides bind to SGLT2 receptors in silico. Matrine has been shown to alleviate pain induced by anticancer drugs, and produce an antinociceptive effect on vincristine-induced painful neuropathy mouse models (Dun et al., 2014) as well as an antinociceptive effect on neuropathic pain induced by chronic constriction injury (Wang, Cao, et al., 2013; Wang, Li, Dun, Xu, Hao, et al., 2013; Wang, Li, Dun, Xu, Jin, et al., 2013). Zhi xue capsule, a preparation that contains two Chinese medicinal herbs, Cortex Dictamnus dasycarpus (bai xian pi) and Radix Sophora flavescens (ku shen), is commonly used to treat hematochezia, anal bulge, and constipation caused by hemorrhoids. If the genitals are swollen and painful, use the following herbs to make a body lotion to wash the genitals: Huang Bai Cortex Phellodendri 10g and Ku Shen Radix Sophorae Flavescentis 10g to eliminate Damp-Heat and relieve the pain, If the testicles are painful, add Ju He Semen Citri Reticulatae 10g and Li Zhi He Semen Litchi 10g to regulate the Liver-Qi and relieve the pain, If there is yellow leucorrhoea, add Ku Shen Radix Sophorae Flavescentis 10g and Bai Xian Pi Cortex Dictamni Radicis 10g to eliminate Damp-Heat in the Lower Burner and relieve the leuokorrhea, If there is constipation, add Da Huang Radix et Rhizoma Rhei 6g and Mang Xiao Natrii Sulfas 10g to clear the Fire, promote the defecation and relieve the constipation. In larger doses, nervous system stimulation with muscle spasm and seizures can occur. Sophora flavescens is a species of plant in the genus Sophora. of family Leguminosae. It may also inhibit the 5-Alpha Reductase enzyme and PDE5 potently, promoting hair growth and erectogenesis. Salvia triloba, traditionally known as Greek sage on bioassay-guided fractionation yielded a variety of flavonoids and terpenoids as modulators (Abdelhalim, Chebib, Aburjai, Johnston, & Hanrahan, 2004) (Fig. Using an in silico receptor docking method, we were able to show that two of the six fenugreek C-glycosides, namely, orientin and vitexin, bound strongly to SGLT2 receptors and exhibited low receptor docking energies (CDock-E) comparable to clinically approved “gliflozins” (Fig. Ku shen (sophora flavescens) is a root with powerful effects on cancer, metabolic diseases, neurological disorders and more. Sophora root is the root of the Sophora flavescens plant. Sophora (Ku Shen) Root . For this patient we used only Chinese herbal medicine: Shui Niu Jiao Bubali Cornu, Sheng Di Huang Rehmanniae Radix and Xuan Shen Scrophulariae Radix to clear pathogenic Heat-Toxin in the Ying and Xuefen; Huang Qin Scutellariae Radix, Bai Xian Pi Dictamni cortex, Zhi Zi Gardeniae Fructus, Tu Fu Ling Smilacis glabrae Rhizoma and Ku Shen Sophorae flavescentis Radix to clear pathogenic Heat-Toxin in the Qifen; Chi Shao Paeoniae Radix rubra and Mu Dan Pi Moutan Cortex to clear Heat and remove Blood stasis; Jing Jie Schizonepetae Herba and Fang Feng Saposhnikoviae Radix to dispel Wind and stop itching; Bai Shao Paeoniae Radix alba to nourish the Blood; and Cang Zhu Atractylodis Rhizoma to prevent a formula with too many bitter tasting and cold herbs from impairing the physiological function of the Stomach and Spleen. Chik WI, Zhu L, Fan LL, Yi T, Zhu GY, Gou XJ, Tang YN, Xu J, Yeung WP, Zhao ZZ, Yu ZL, Chen HB. K. Chan, ... Z.X. A herbal record lists the following adverse effects of Ku shen: salivation, abnormal gait, dyspnea, tachycardia [85]. It is indicated in copulation pain due to formation of Damp-Heat resulting from weakness of the Spleen. J Ethnobiol Ethnomed. Product Description. Sophora falvescens (Ku shen) contains a variety of matrine alkaloids, such as aloperine, cytosine, lehmannine, matrine, oxymartine, oxysophocarpine, sophocarpine, sophoramine, and sophoridine, the flavonoid kushenol, and the saponin sophoraflavoside. We believe that Ku Shen has great potential as a novel analgesic agent due to its multiple targets of action. Ku shen is a Chinese herbal remedy made from the root of S. falvescens. Cancer Treatment : Useful in treating Cancer of Reproductive Organs, Respiratory Tract and Liver Cancer. Johnston, in, Yang, Baburin, Plitzko, Hering, & Hamburger, 2011, Kavvadias, Monschein, Sand, Riederer, & Schreier, 2003; Kavvadias et al., 2004, Abdelhalim, Chebib, Aburjai, Johnston, & Hanrahan, 2004, Goutman, Waxemberg, Donate-Oliver, Pomata, & Calvo, 2003, Gavande, Karim, Johnston, Hanrahan, & Chebib, 2011, Wanzhu Hou CMD LAc DiplAC DiplCH (NCCAOM), ... Hanjie Wang MD, in, Treating Autoimmune Disease with Chinese Medicine, Renal Sodium-Glucose Transporter-2 Inhibitors as Antidiabetic Agents, Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome (Second Edition), Anika Niambi Al-Shura BSc., MSOM, Ph.D, in, Integrative Cardiovascular Chinese Medicine, The Treatment of Pain with Chinese Herbs and Acupuncture (Second Edition), Journal of Allergy and Clinical Immunology, The Microbiology of Skin, Soft Tissue, Bone and Joint Infections. It has a medicinal history of more than 2,000 years. Materials and methods: Collected in spring and autumn. Unprocessed. COVID-19 is an emerging, rapidly evolving situation. eCollection 2020. USA.gov. In Chinese, Ku Shen means “bitter root”. If there is a painful perineum, add CV-1 and KI-6 to clear Damp-Heat and relieve the pain in the perineum, If there are swollen genitals, add SP-6 to eliminate Damp-Heat and reduce the swelling, If the testicles are painful, add ST-29 and ST-30 to regulate the Qi, remove its stagnation and relieve the pain, If there is a painful vagina with leucorrhoea, add ST-30 and HT-8 to eliminate Damp-Heat and relieve the pain, If there is painful urination, add KI-4 to clear Damp-Heat, promote the urination and relieve the pain. We systematically searched major scientific databases (PubMed, Elsevier, SpringerLink, Google Scholar, Medline Plus, ACS, "Da Yi Yi Xue Sou Suo (http://www.dayi100.com/login.jsp)", China Knowledge Resource Integrated (CNKI) and Web of Science) for information published between 1958 and 2015 on Sophora flavescens. Several compounds present in Ku Shen have shown an analgesic effect, including matrine, oxymatrine, sophocarpine, and oxysophocarpine. 2016 Jul 1;187:160-82. doi: 10.1016/j.jep.2016.04.014. The objective of this paper was to isolate, purify and identify alkaloids from Sophora flavescens Ait. It is hardy to zone (UK) 6. Studies were carried out with Discovery Studio 3.1 (Accelrys, San Diego, CA) on an Intel Xeon 5600 series. Natural and synthetic flavonoids. Wanzhu Hou CMD LAc DiplAC DiplCH (NCCAOM), ... Hanjie Wang MD, in Treating Autoimmune Disease with Chinese Medicine, 2011. Further studies have shown that quercetin antagonizes GABAC receptors through a redox-independent allosteric mechanism that is prevented by ascorbic acid (Calero et al., 2013). It’s an herbal remedy used in Traditional Chinese Medicine, where it is known as Ku Shen. The principal component of kushen is the piperidine alkaloid matrine.142 Berberine, which is isolated from the bark of Phellodendron amurense (Rutaceae) as well as Coptis japonica Makino (Ranunculaceae), is also an intensely bitter-tasting alkaloid that is named after Berberis.143 There are a variety of known derivatives such as berberine hydrochloride, hydrosulfate, and tannic acid salt according to the kind of counteranion, and all are used as stegnotic agents. 25. Anand S. Nair, ... Sreejayan Nair, in Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome (Second Edition), 2018, As the prototypical SGLT inhibitor phlorizin was first identified from the bark of the root of the apple tree, it is not surprising that several plant-based molecules may possess SGLT2 inhibitory activity and therefore emerge as potential drugs or drug templates. Processing. 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